Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder

Nagahide Takahashi; Tomoko Nishimura; Akemi Okumura; Taeko Harada; Toshiki Iwabuchi; Md Shafiur Rahman; Pi-Hua Liu; Gwo-Tsann Chuang; Yi-Cheng Chang; Yoko Nomura; Kenji J. Tsuchiya

Psychiatry Research Communications (Sep 2024)

Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder

Nagahide Takahashi,
Tomoko Nishimura,
Akemi Okumura,
Taeko Harada,
Toshiki Iwabuchi,
Md Shafiur Rahman,
Pi-Hua Liu,
Gwo-Tsann Chuang,
Yi-Cheng Chang,
Yoko Nomura,
Kenji J. Tsuchiya

Affiliations

Nagahide Takahashi: Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan; Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan; Corresponding author. Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya city, Aichi, 466-8550, Japan.
Tomoko Nishimura: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan
Akemi Okumura: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan
Taeko Harada: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan
Toshiki Iwabuchi: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan
Md Shafiur Rahman: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan
Pi-Hua Liu: Department of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei, Taiwan
Gwo-Tsann Chuang: Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
Yi-Cheng Chang: Department of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Yoko Nomura: Queens College and Graduate Center, City University of New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Kenji J. Tsuchiya: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan

Journal volume & issue: Vol. 4, no. 3
p. 100188

Abstract

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Sleep problems are common in individuals with ADHD; however, the exact underlying mechanism is unknown. I Data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (N = 27,076), the Taiwan Biobank (N = 2373) and the Hamamatsu Birth Cohort for Mothers and Children (N = 726) were used for analysis. Linkage disequilibrium score-based genetic correlation showed a genetic correlation between melatonin secretion and ADHD diagnosis (rg[SD] = -0.134 [0.012], P < 0.001). Polygenic risk score analyses revealed that genetic variants related to melatonin secretion were associated with ADHD symptoms (beta [SD] = -0.077[0.033], P = 0.019). Dysregulation of melatonin secretion may be associated with the risk of ADHD.

Published in Psychiatry Research Communications

ISSN: 2772-5987 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.journals.elsevier.com/psychiatry-research-communications

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