Marijuana Use May Be Associated with Reduced Prevalence of Prostate Cancer: A National Survey on Drug Use and Health Study from United States of America
Turab Mohammed,
James Yu,
Yong Qiao,
Youngchul Kim,
Eric Mortensen,
Helen Swede,
Zhao Wu,
Jingsong Zhang
Affiliations
Turab Mohammed
Department of Hematology-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
James Yu
Department of Hematology-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Yong Qiao
Department of Statistics, University of Connecticut, Storrs, CT 06269, USA
Youngchul Kim
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Eric Mortensen
Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06032, USA
Helen Swede
Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT 06032, USA
Zhao Wu
Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
Jingsong Zhang
Department of Genito-Urology Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Preclinical evidence indicates the potential anti-tumor capabilities of cannabinoids in prostate cancer (PC). We undertook a cross-sectional study using National Survey on Drug Use and Health data from 2002 to 2020, involving 2503 participants in the USA. The independent variable was marijuana use status (current, former, never), while the dependent variable was self-reported PC (yes, no). Eleven other demographic variables were assessed as covariates. PC prevalence was lower among current marijuana users (46/145, 31.7%) and former users (323/1021, 31.6%) compared to non-users (534/1337, 39.9%, p p = 0.016) and non-Hispanic white subgroups (28.9% vs. 38.3%, p p = 0.001). Current use was also suggestive of reduced prevalence but was not statistically significant (odd ratio = 0.77, 95% CI 0.52–1.14, p = 0.198), possibly due to low sample size. Our findings from a large national survey provide additional data to link marijuana use with lower PC prevalence.
