Frontiers in Behavioral Neuroscience (May 2020)
The MAOA Gene Influences the Neural Response to Psychosocial Stress in the Human Brain
- Xiaoqiang Sun,
- Xiaoqiang Sun,
- Xiaoqiang Sun,
- Qingsen Ming,
- Qingsen Ming,
- Xue Zhong,
- Xue Zhong,
- Xue Zhong,
- Daifeng Dong,
- Daifeng Dong,
- Daifeng Dong,
- Chuting Li,
- Chuting Li,
- Chuting Li,
- Ge Xiong,
- Ge Xiong,
- Ge Xiong,
- Chang Cheng,
- Chang Cheng,
- Chang Cheng,
- Wanyi Cao,
- Wanyi Cao,
- Wanyi Cao,
- Jiayue He,
- Jiayue He,
- Jiayue He,
- Xiang Wang,
- Xiang Wang,
- Xiang Wang,
- Jinyao Yi,
- Jinyao Yi,
- Jinyao Yi,
- Shuqiao Yao,
- Shuqiao Yao,
- Shuqiao Yao
Affiliations
- Xiaoqiang Sun
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiaoqiang Sun
- Medical Psychological Institute of Central South University, Changsha, China
- Xiaoqiang Sun
- National Clinical Research Center for Mental Disorders, Changsha, China
- Qingsen Ming
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Qingsen Ming
- Department of Psychiatry, The First Affiliated Hospital of Sochoow University, Suzhou, China
- Xue Zhong
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Xue Zhong
- Medical Psychological Institute of Central South University, Changsha, China
- Xue Zhong
- National Clinical Research Center for Mental Disorders, Changsha, China
- Daifeng Dong
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Daifeng Dong
- Medical Psychological Institute of Central South University, Changsha, China
- Daifeng Dong
- National Clinical Research Center for Mental Disorders, Changsha, China
- Chuting Li
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Chuting Li
- Medical Psychological Institute of Central South University, Changsha, China
- Chuting Li
- National Clinical Research Center for Mental Disorders, Changsha, China
- Ge Xiong
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Ge Xiong
- Medical Psychological Institute of Central South University, Changsha, China
- Ge Xiong
- National Clinical Research Center for Mental Disorders, Changsha, China
- Chang Cheng
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Chang Cheng
- Medical Psychological Institute of Central South University, Changsha, China
- Chang Cheng
- National Clinical Research Center for Mental Disorders, Changsha, China
- Wanyi Cao
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Wanyi Cao
- Medical Psychological Institute of Central South University, Changsha, China
- Wanyi Cao
- National Clinical Research Center for Mental Disorders, Changsha, China
- Jiayue He
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Jiayue He
- Medical Psychological Institute of Central South University, Changsha, China
- Jiayue He
- National Clinical Research Center for Mental Disorders, Changsha, China
- Xiang Wang
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiang Wang
- Medical Psychological Institute of Central South University, Changsha, China
- Xiang Wang
- National Clinical Research Center for Mental Disorders, Changsha, China
- Jinyao Yi
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Jinyao Yi
- Medical Psychological Institute of Central South University, Changsha, China
- Jinyao Yi
- National Clinical Research Center for Mental Disorders, Changsha, China
- Shuqiao Yao
- Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China
- Shuqiao Yao
- Medical Psychological Institute of Central South University, Changsha, China
- Shuqiao Yao
- National Clinical Research Center for Mental Disorders, Changsha, China
- DOI
- https://doi.org/10.3389/fnbeh.2020.00065
- Journal volume & issue
-
Vol. 14
Abstract
The stress response is regulated by many mechanisms. Monoamine oxidase A (MAOA) has been related to many mental illnesses. However, few studies have explored the relationship between MAOA and acute laboratory-induced psychosocial stress with functional magnetic resonance imaging (fMRI). In the current study, the Montreal Imaging Stress Task (MIST) and fMRI were used to investigate how MAOA influences the stress response. Increased cortisol concentrations were observed after the task; functional connectivity between the bilateral anterior hippocampus and other brain regions was reduced during stress. MAOA-H allele carriers showed greater deactivation of the right anterior hippocampus and greater cortisol response after stress than did MAOH-L allele carriers. Hippocampal deactivation may lead to disinhibition of the hypothalamic-pituitary-adrenal (HPA) axis and the initiation of stress hormone release under stress. Our results suggest that the MAOA gene regulates the stress response by influencing the right anterior hippocampus.
Keywords
