mBio
(Oct 2021)
On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)
Melina M. B. Martínez,
Robert A. Bonomo,
Alejandro J. Vila,
Paulo C. Maffía,
Lisandro J. González
Affiliations
Melina M. B. Martínez
ORCiD Laboratorio de Microbiología Molecular, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina
Robert A. Bonomo
ORCiD Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA
Alejandro J. Vila
ORCiD CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA
Paulo C. Maffía
ORCiD Laboratorio de Microbiología Molecular, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina
Lisandro J. González
ORCiD Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina
DOI
https://doi.org/10.1128/mBio.01836-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Resistance to carbapenems, last-resort antibiotics, is spreading worldwide, raising great concern. NDM-1 is one of the most potent and widely disseminated carbapenem-hydrolyzing enzymes spread among many bacteria and is secreted to the extracellular medium within outer membrane vesicles.
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