Frontiers in Medicine (Jul 2021)
Routine Hematological Parameters May Be Predictors of COVID-19 Severity
- Paulina B. Szklanna,
- Paulina B. Szklanna,
- Haidar Altaie,
- Shane P. Comer,
- Shane P. Comer,
- Sarah Cullivan,
- Sarah Kelliher,
- Luisa Weiss,
- Luisa Weiss,
- John Curran,
- Emmet Dowling,
- Katherine M. A. O'Reilly,
- Katherine M. A. O'Reilly,
- Aoife G. Cotter,
- Aoife G. Cotter,
- Aoife G. Cotter,
- Brian Marsh,
- Brian Marsh,
- Sean Gaine,
- Sean Gaine,
- Nick Power,
- Nick Power,
- Áine Lennon,
- Brian McCullagh,
- Brian McCullagh,
- Fionnuala Ní Áinle,
- Fionnuala Ní Áinle,
- Fionnuala Ní Áinle,
- Fionnuala Ní Áinle,
- Barry Kevane,
- Barry Kevane,
- Barry Kevane,
- Patricia B. Maguire,
- Patricia B. Maguire,
- Patricia B. Maguire
Affiliations
- Paulina B. Szklanna
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Paulina B. Szklanna
- School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
- Haidar Altaie
- SAS UK Headquarters, Wittington House, Buckinghamshire, United Kingdom
- Shane P. Comer
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Shane P. Comer
- School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
- Sarah Cullivan
- Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
- Sarah Kelliher
- Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
- Luisa Weiss
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Luisa Weiss
- School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
- John Curran
- SAS Institute Ltd., La Touche House, Dublin, Ireland
- Emmet Dowling
- SAS Institute Ltd., La Touche House, Dublin, Ireland
- Katherine M. A. O'Reilly
- Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
- Katherine M. A. O'Reilly
- School of Medicine, University College Dublin, Dublin, Ireland
- Aoife G. Cotter
- School of Medicine, University College Dublin, Dublin, Ireland
- Aoife G. Cotter
- UCD Centre for Experimental Pathogen and Host Research, Dublin, Ireland
- Aoife G. Cotter
- Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland
- Brian Marsh
- School of Medicine, University College Dublin, Dublin, Ireland
- Brian Marsh
- 0Department of Critical Care Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
- Sean Gaine
- Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
- Sean Gaine
- School of Medicine, University College Dublin, Dublin, Ireland
- Nick Power
- School of Medicine, University College Dublin, Dublin, Ireland
- Nick Power
- Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland
- Áine Lennon
- Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
- Brian McCullagh
- Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
- Brian McCullagh
- School of Medicine, University College Dublin, Dublin, Ireland
- Fionnuala Ní Áinle
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Fionnuala Ní Áinle
- Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
- Fionnuala Ní Áinle
- School of Medicine, University College Dublin, Dublin, Ireland
- Fionnuala Ní Áinle
- 1Department of Haematology, Rotunda Hospital, Dublin, Ireland
- Barry Kevane
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Barry Kevane
- Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
- Barry Kevane
- School of Medicine, University College Dublin, Dublin, Ireland
- Patricia B. Maguire
- Conway SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
- Patricia B. Maguire
- School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
- Patricia B. Maguire
- 2UCD Institute for Discovery, University College Dublin, Dublin, Ireland
- DOI
- https://doi.org/10.3389/fmed.2021.682843
- Journal volume & issue
-
Vol. 8
Abstract
To date, coronavirus disease 2019 (COVID-19) has affected over 100 million people globally. COVID-19 can present with a variety of different symptoms leading to manifestation of disease ranging from mild cases to a life-threatening condition requiring critical care-level support. At present, a rapid prediction of disease severity and critical care requirement in COVID-19 patients, in early stages of disease, remains an unmet challenge. Therefore, we assessed whether parameters from a routine clinical hematology workup, at the time of hospital admission, can be valuable predictors of COVID-19 severity and the requirement for critical care. Hematological data from the day of hospital admission (day of positive COVID-19 test) for patients with severe COVID-19 disease (requiring critical care during illness) and patients with non-severe disease (not requiring critical care) were acquired. The data were amalgamated and cleaned and modeling was performed. Using a decision tree model, we demonstrated that routine clinical hematology parameters are important predictors of COVID-19 severity. This proof-of-concept study shows that a combination of activated partial thromboplastin time, white cell count-to-neutrophil ratio, and platelet count can predict subsequent severity of COVID-19 with high sensitivity and specificity (area under ROC 0.9956) at the time of the patient's hospital admission. These data, pending further validation, indicate that a decision tree model with hematological parameters could potentially form the basis for a rapid risk stratification tool that predicts COVID-19 severity in hospitalized patients.
Keywords
