Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
Fenglin Wu,
Jun Ma,
Junli Xue,
Xue Jiang,
Jinyu Liu,
Jiashuo Zhang,
Yazhuo Xue,
Boyan Liu,
Shucun Qin
Affiliations
Fenglin Wu
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; College of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China
Jun Ma
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
Junli Xue
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Xue Jiang
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Jinyu Liu
College of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China
Jiashuo Zhang
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; Taishan Vocational College of Nursing, Tai'an, China
Yazhuo Xue
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; College of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China; Corresponding author. Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Boyan Liu
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; Corresponding author.
Shucun Qin
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China; Corresponding author.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits. Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia. Methods: The Placebo group consumed three bottles of ordinary drinking water (330 mL per bottle), the Low-HRW group consumed two bottles of HRW (330 mL per bottle, H2 ≥ 4.66 mg/L) and a bottle of ordinary water, and the High-HRW group consumed three bottles of HRW daily for 8 weeks. The primary outcome was the blood uric acid levels following different time points (4 and 8 weeks) compared to baseline. Results: A total of 100 participants completed the entire trial (32 in Placebo, 35 in Low-HRW, and 33 in High-HRW groups). The high-dose of HRW was more effective than low-dose HRW in controlling blood uric acid. Following an 8-week period, the High-HRW group exhibited a significant reduction in blood uric acid levels compared to the baseline (488.2 ± 54.1 μmol/L to 446.8 ± 57.1 μmol/L, P < 0.05). Conclusion: As a rather safe agent, the prolonged consumption of HRW may be feasible in the management of hyperuricemia. Clinical trial registration: chictr.org.cn, identifier ChiCTR2200066369.
