Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Ning Huang; Yuqing Xia; Donghui Zhang; Song Wang; Yitian Bao; Runsheng He; Junlin Teng; Jianguo Chen

doi:10.1038/ncomms15057

Nature Communications (Apr 2017)

Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Ning Huang,
Yuqing Xia,
Donghui Zhang,
Song Wang,
Yitian Bao,
Runsheng He,
Junlin Teng,
Jianguo Chen

Affiliations

Ning Huang: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Yuqing Xia: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Donghui Zhang: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Song Wang: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Yitian Bao: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Runsheng He: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Junlin Teng: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University
Jianguo Chen: Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University

DOI: https://doi.org/10.1038/ncomms15057
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly and centrosome microtubule anchoring.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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