Nature Communications (Jan 2022)
Skeletal muscle derived Musclin protects the heart during pathological overload
- Malgorzata Szaroszyk,
- Badder Kattih,
- Abel Martin-Garrido,
- Felix A. Trogisch,
- Gesine M. Dittrich,
- Andrea Grund,
- Aya Abouissa,
- Katja Derlin,
- Martin Meier,
- Tim Holler,
- Mortimer Korf-Klingebiel,
- Katharina Völker,
- Tania Garfias Macedo,
- Cristina Pablo Tortola,
- Michael Boschmann,
- Nora Huang,
- Natali Froese,
- Carolin Zwadlo,
- Mona Malek Mohammadi,
- Xiaojing Luo,
- Michael Wagner,
- Julio Cordero,
- Robert Geffers,
- Sandor Batkai,
- Thomas Thum,
- Nadja Bork,
- Viacheslav O. Nikolaev,
- Oliver J. Müller,
- Hugo A. Katus,
- Ali El-Armouche,
- Theresia Kraft,
- Jochen Springer,
- Gergana Dobreva,
- Kai C. Wollert,
- Jens Fielitz,
- Stephan von Haehling,
- Michaela Kuhn,
- Johann Bauersachs,
- Joerg Heineke
Affiliations
- Malgorzata Szaroszyk
- Department of Cardiology and Angiology, Hannover Medical School
- Badder Kattih
- Department of Cardiology and Angiology, Hannover Medical School
- Abel Martin-Garrido
- Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Felix A. Trogisch
- Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Gesine M. Dittrich
- Department of Cardiology and Angiology, Hannover Medical School
- Andrea Grund
- Department of Cardiology and Angiology, Hannover Medical School
- Aya Abouissa
- Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Katja Derlin
- Institute for Diagnostic and Interventional Radiology, Hannover Medical School
- Martin Meier
- Central Animal Facility, Hannover Medical School
- Tim Holler
- Institute of Molecular and Cell Physiology, Hannover Medical School
- Mortimer Korf-Klingebiel
- Department of Cardiology and Angiology, Hannover Medical School
- Katharina Völker
- Institute of Physiology and Comprehensive Heart Failure Center, University of Würzburg
- Tania Garfias Macedo
- Department of Cardiology and Pneumology, University of Göttingen Medical Center, DZHK (German Center for Cardiovascular Research), partner site Göttingen
- Cristina Pablo Tortola
- Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association
- Michael Boschmann
- Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association
- Nora Huang
- Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association
- Natali Froese
- Department of Cardiology and Angiology, Hannover Medical School
- Carolin Zwadlo
- Department of Cardiology and Angiology, Hannover Medical School
- Mona Malek Mohammadi
- Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Xiaojing Luo
- Institute of Pharmacology and Toxicology, Dresden University of Technology
- Michael Wagner
- Institute of Pharmacology and Toxicology, Dresden University of Technology
- Julio Cordero
- Anatomy and Developmental Biology, ECAS, Medical Faculty Mannheim, Heidelberg University
- Robert Geffers
- RG Genome Analytics, Helmholtz Center for Infection Research
- Sandor Batkai
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Thomas Thum
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Nadja Bork
- Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf
- Viacheslav O. Nikolaev
- Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf
- Oliver J. Müller
- Department of Internal Medicine III, University Hospital Schleswig-Holstein
- Hugo A. Katus
- Department of Cardiology, Angiology, and Pneumology, Internal Medicine III, University Hospital Heidelberg
- Ali El-Armouche
- Institute of Pharmacology and Toxicology, Dresden University of Technology
- Theresia Kraft
- Institute of Molecular and Cell Physiology, Hannover Medical School
- Jochen Springer
- Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT)
- Gergana Dobreva
- Anatomy and Developmental Biology, ECAS, Medical Faculty Mannheim, Heidelberg University
- Kai C. Wollert
- Department of Cardiology and Angiology, Hannover Medical School
- Jens Fielitz
- Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association
- Stephan von Haehling
- Department of Cardiology and Pneumology, University of Göttingen Medical Center, DZHK (German Center for Cardiovascular Research), partner site Göttingen
- Michaela Kuhn
- Institute of Physiology and Comprehensive Heart Failure Center, University of Würzburg
- Johann Bauersachs
- Department of Cardiology and Angiology, Hannover Medical School
- Joerg Heineke
- Department of Cardiology and Angiology, Hannover Medical School
- DOI
- https://doi.org/10.1038/s41467-021-27634-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens, while its muscle-specific overexpression ameliorates heart failure in mice.
