Highly sensitive Ag/BaTiO3/MoS2 nano composite layer based SPR sensor for detection of blood and cervical cancer

Vikash Kumar; Sanjeev Kumar Raghuwanshi; Santosh Kumar

Results in Optics (Feb 2024)

Highly sensitive Ag/BaTiO3/MoS2 nano composite layer based SPR sensor for detection of blood and cervical cancer

Vikash Kumar,
Sanjeev Kumar Raghuwanshi,
Santosh Kumar

Affiliations

Vikash Kumar: Department of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, India; Department of Electrical Engineering, GLA University, Mathura 281406, India
Sanjeev Kumar Raghuwanshi: Department of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, India; Corresponding authors at: Department of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Department of Electronics Engineering, Dhanbad 826004, India and Department of Electronics and Communication Engineering, K L Deemed to be University, Guntur, Andhra Pradesh, 522302, India.
Santosh Kumar: Department of Electronics and Communication Engineering, K L Deemed to be University, Guntur, Andhra Pradesh 522302, India; Corresponding authors at: Department of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Department of Electronics Engineering, Dhanbad 826004, India and Department of Electronics and Communication Engineering, K L Deemed to be University, Guntur, Andhra Pradesh, 522302, India.

Journal volume & issue: Vol. 14
p. 100597

Abstract

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In this article, a nano-composite Ag/BaTiO3/MoS2 multilayer coating-based surface plasmon resonance (SPR) sensor with high sensitivity and figure of merit for the detection of cancer cells is analyzed. The proposed SPR biomedical sensor structure is built on the angular interrogation approach to utilizing the refractive index component, attenuated total reflection (ATR) analysis is employed to identify different kinds of cancer cells. The resonance angle varied as the refractive index (RI) of healthy and cancerous cells changed. Which ranged from 1.368 to 1.392 for increasing concentration in cervical (HeLa cells) and blood (Jurkat cells), RI 1.376 to 1.390 changes as the concentration of cancerous cells increases in healthy cells. The maximum estimated sensitivities for cervical (HeLa) and blood (Jurkat) cancer cells based on numerical data were 271.25 deg/RIU and 290.714 deg/RIU, respectively. The proposed BK7/Ag/BaTiO3/ MoS2 has the ability to identify cancerous and healthy cells with the greatest overall sensitivity, as demonstrated by layered structures. Finally, the numerical results analyzed in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.

Published in Results in Optics

ISSN: 2666-9501 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Optics. Light
Website: https://www.journals.elsevier.com/results-in-optics

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