Nature Communications (Aug 2016)
Identification of Siglec-1 null individuals infected with HIV-1
- Javier Martinez-Picado,
- Paul J. McLaren,
- Itziar Erkizia,
- Maureen P. Martin,
- Susana Benet,
- Margalida Rotger,
- Judith Dalmau,
- Dan Ouchi,
- Steven M. Wolinsky,
- Sudhir Penugonda,
- Huldrych F. Günthard,
- Jacques Fellay,
- Mary Carrington,
- Nuria Izquierdo-Useros,
- Amalio Telenti
Affiliations
- Javier Martinez-Picado
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Paul J. McLaren
- National HIV and Retrovirology Laboratory, Public Health Agency of Canada
- Itziar Erkizia
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Maureen P. Martin
- Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- Susana Benet
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Margalida Rotger
- Institute of Microbiology, University Hospital Center and University of Lausanne
- Judith Dalmau
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Dan Ouchi
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Steven M. Wolinsky
- Department of Medicine, Northwestern University Feinberg School of Medicine
- Sudhir Penugonda
- Department of Medicine, Northwestern University Feinberg School of Medicine
- Huldrych F. Günthard
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
- Jacques Fellay
- School of Life Sciences, École Polytechnique Fédérale de Lausanne
- Mary Carrington
- Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- Nuria Izquierdo-Useros
- AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona
- Amalio Telenti
- Genomic Medicine, J. Craig Venter Institute
- DOI
- https://doi.org/10.1038/ncomms12412
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 7
Abstract
Binding of virus, HIV-1, to cellular protein Siglec-1 is important for infection of immune cells. Here the authors show that a natural mutation leading to production of truncated Siglec-1 reduces HIV binding and infectivity transfer in vitro, but does not substantially affect infection or AIDS outcome in patients.
