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The Effect of Hydroalcoholic Extract of Salvia Officinalis on Gonadotropin, and Sex Steroids in Adult Diabetic Male Rat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd. 2016;23(10):1018-1027


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Journal Title: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd

ISSN: 2228-5741 (Print); 2228-5733 (Online)

Publisher: Shahid Sadoughi University of Medical Sciences

LCC Subject Category: Medicine: Medicine (General)

Country of publisher: Iran, Islamic Republic of

Language of fulltext: Persian

Full-text formats available: PDF



M Mirchenari ( Islamic Azad University )

M Mokhtari ( Islamic Azad University )

M Shariati ( Islamic Azad University )


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks


Abstract | Full Text

Introduction: Diabetes mellitus has been demonstrated to affect the reproductive system. The current study aimed to investigate the effect of hydroalcoholic extract of Salvia officinalis (SO) on the serum levels of gonadotropin, testosterone and dihydrotestosterone. Methods: In the present study, 60 adult male Wistar rats were divided  into 5 groups (n=10) as follows: control, Stereptozotocine- treated diabetic (60 mg/kg), SO- treated control (400 mg/ kg), SO - treated diabetic (200 mg/ kg), SO - treated diabetic (400mg/kg). After 28 days, the blood samples were prepared  and hormones levels were measured by the radio-immunoassay method. Results: Serum levels of hormones significantly decreased in the diabetic group compared to the control group. Serum levels of testosterone and dihydrotestosterone were reported to be higher and lower in SO- treated control group, respectively. Gonadotropin and testosterone were significantly demonstrated to be higher in the diabetic groups treated with the extract (200 mg/ kg,400 mg/kg) compared with the diabetic group. Conclusion: The findings of the present study indicated that extract of Salvia officinalis, containing quercetin and Rosmarinic acid, induces a protective effect on the cells destroyed by streptozotocin, which has been proved to be effective in reducing the complications of diabetes and maintaining a serum level of hormones in the rats.