Genetic Predisposition to Neurological Complications in Patients with COVID-19
Nikhil Shri Sahajpal,
Alex R. Hastie,
Maximilian Schieck,
Ashis K. Mondal,
Marc Felde,
Caspar I. van der Made,
Janet S. Chou,
Adrienne G. Randolph,
Thomas Illig,
Michael C. Zody,
Catherine A. Brownstein,
Alan H. Beggs,
Alexander Hoischen,
Alka Chaubey,
Ravindra Kolhe
Affiliations
Nikhil Shri Sahajpal
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Alex R. Hastie
Bionano Genomics, Inc., San Diego, CA 92121, USA
Maximilian Schieck
Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany
Ashis K. Mondal
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Marc Felde
Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany
Caspar I. van der Made
Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands
Janet S. Chou
Division of Immunology, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Adrienne G. Randolph
Department of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Thomas Illig
Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany
Michael C. Zody
New York Genome Center, New York, NY 10013, USA
Catherine A. Brownstein
Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Alan H. Beggs
Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Alexander Hoischen
Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands
Alka Chaubey
Bionano Genomics, Inc., San Diego, CA 92121, USA
Ravindra Kolhe
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.
