Communications Biology (Jan 2023)
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients
- Lauren A. Peters,
- Joshua R. Friedman,
- Aleksandar Stojmirovic,
- Jacob Hagen,
- Sander Houten,
- Tetyana Dodatko,
- Mariana P. Amaro,
- Paula Restrepo,
- Zhi Chai,
- J. Rodrigo Mora,
- Holly A. Raymond,
- Mark Curran,
- Radu Dobrin,
- Anuk Das,
- Huabao Xiong,
- Eric E. Schadt,
- Carmen Argmann,
- Bojan Losic
Affiliations
- Lauren A. Peters
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Joshua R. Friedman
- Spark Therapeutics
- Aleksandar Stojmirovic
- Janssen Research & Development, LLC, Spring House
- Jacob Hagen
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Sander Houten
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Tetyana Dodatko
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Mariana P. Amaro
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Paula Restrepo
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Zhi Chai
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- J. Rodrigo Mora
- Janssen Research & Development, LLC, Spring House
- Holly A. Raymond
- Janssen Research & Development, LLC, Spring House
- Mark Curran
- Janssen Research & Development, LLC, Spring House
- Radu Dobrin
- Janssen Research & Development, LLC, Spring House
- Anuk Das
- Janssen Research & Development, LLC, Spring House
- Huabao Xiong
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Carmen Argmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Bojan Losic
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s42003-023-04469-y
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 12
Abstract
Longitudinal changes in gene expression, splicing patterns and adaptive immune repertoire in murine models of colitis are examined and associated with histologic inflammation in mice and in patients with inflammatory bowel disease.
