Frontiers in Bioengineering and Biotechnology (Oct 2022)

Rare-earth doped BiFe0.95Mn0.05O3 nanoparticles for potential hyperthermia applications

  • Astita Dubey,
  • Soma Salamon,
  • Supun B. Attanayake,
  • Syaidah Ibrahim,
  • Joachim Landers,
  • Marianela Escobar Castillo,
  • Heiko Wende,
  • Hari Srikanth,
  • Vladimir V. Shvartsman,
  • Doru C. Lupascu

DOI
https://doi.org/10.3389/fbioe.2022.965146
Journal volume & issue
Vol. 10

Abstract

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Ionic engineering is exploited to substitute Bi cations in BiFe0.95Mn0.05O3 NPs (BFM) with rare-earth (RE) elements (Nd, Gd, and Dy). The sol-gel synthesized RE-NPs are tested for their magnetic hyperthermia potential. RE-dopants alter the morphology of BFM NPs from elliptical to rectangular to irregular hexagonal for Nd, Gd, and Dy doping, respectively. The RE-BFM NPs are ferroelectric and show larger piezoresponse than the pristine BFO NPs. There is an increase of the maximum magnetization at 300 K of BFM up to 550% by introducing Gd. In hyperthermia tests, 3 mg/ml dispersion of NPs in water and agar could increase the temperature of the dispersion up to ∼39°C under an applied AC magnetic field of 80 mT. Although Gd doping generates the highest increment in magnetization of BFM NPs, the Dy-BFM NPs show the best hyperthermia results. These findings show that RE-doped BFO NPs are promising for hyperthermia and other biomedical applications.

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