Nature Communications (Feb 2016)

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

  • Michael S. Nakazawa,
  • T. S. Karin Eisinger-Mathason,
  • Navid Sadri,
  • Joshua D. Ochocki,
  • Terence P. F. Gade,
  • Ruchi K. Amin,
  • M. Celeste Simon

DOI
https://doi.org/10.1038/ncomms10539
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo.