Medicina v Kuzbasse (Oct 2017)
TOXICOLOGICAL EVALUATION OF 1.1.3-TRICHLORO-3-PHENYLPROPANE AS A RISK FACTOR FOR WORKERS’ HEALTH
Abstract
Subject. The toxic properties of 1.1.3-trichloro-3-phenylpropane (ChPhP). Objective. Hygienic regulation of 1.1.3-trichloro-3-phenylpropane in the air of the work area to minimize the risk to the workers’ health in the chemical and pharmaceutical production. Methods. Experimental studies were carried out on nonlinear white mice and rats, Guinea pigs of light color and rabbits. The toxic ChPhP properties were studied in single and repeated experiments under oral, percutaneous and inhalation exposure. The study of the sensitizing properties of the substance was carried out with a single intradermal introduction to Guinea pigs. Statistical processing of the study results was performed using «Statistica» software package. Main results. Median lethal dose (DL50) of the substance when introduced into the stomach for male rats and male female mice is 4130, 1670 and 2080 mg/kg, respectively (hazard class III according to the All-Union State Standard 12.1.007-76). There were no significant differences in species and sex sensitivity to ChPhP: the coefficient of species differences was 2.47, the coefficient of sexual sensitivity was 1.25. It has a low cumulative ability: the cumulation coefficient (Ccum) is 6.2. It has a mild irritant effect on the skin and a weak one on the mucous eye membranes. It has a skin-resorptive effect. In a subacute experiment, it is primarily a hepatotropic effect. The threshold of acute inhalation action is 50.7 mg/m3. The tentative safe exposure level (TSEL) in the air of the work area is 2 mg/m3. Scope of application. Hygienic regulation of adverse substances in the air of the work area. Conclusions. TSEL of 1.1.3-trichloro-3-phenylpropane in the air of the work zone was approved and legislated – 2 mg/m3, the aggregate state – vapors with the mark «special protection of the skin and eyes» (Hygienic Standards 2.2.5.2308-07). The control method in the air of the work area is photometric. Compliance with this standard will minimize the risk to workers’ health.
