T-cell stimuli independently sum to regulate an inherited clonal division fate

J. M. Marchingo; G. Prevedello; A. Kan; S. Heinzel; P. D. Hodgkin; K. R. Duffy

doi:10.1038/ncomms13540

Nature Communications (Nov 2016)

T-cell stimuli independently sum to regulate an inherited clonal division fate

J. M. Marchingo,
G. Prevedello,
A. Kan,
S. Heinzel,
P. D. Hodgkin,
K. R. Duffy

Affiliations

J. M. Marchingo: Division of Immunology, The Walter and Eliza Hall Institute of Medical Research
G. Prevedello: Hamilton Institute, Maynooth University
A. Kan: Division of Immunology, The Walter and Eliza Hall Institute of Medical Research
S. Heinzel: Division of Immunology, The Walter and Eliza Hall Institute of Medical Research
P. D. Hodgkin: Division of Immunology, The Walter and Eliza Hall Institute of Medical Research
K. R. Duffy: Hamilton Institute, Maynooth University

DOI: https://doi.org/10.1038/ncomms13540
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in division destiny is a result of inter-clonal variability as lineage imprinting ensures clones share similar proliferation fates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal