Медицинская иммунология (Jul 2014)

PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

  • A. N. Silkov,
  • N. S. Shkaruba,
  • T. A. Kalashnikova,
  • L. P. Sizyakina,
  • J. B. Shulman,
  • S. V. Dolgikh,
  • V. I. Mazurov,
  • O. A. Gerzog,
  • A. E. Sizikov,
  • V. A. Kozlov,
  • S. V. Sennikov

DOI
https://doi.org/10.15789/1563-0625-2012-1-2-81-86
Journal volume & issue
Vol. 14, no. 1-2
pp. 81 – 86

Abstract

Read online

Abstract. Prevalence of TNFα gene promoter polymorphism at -857 position was investigated in normal persons and among patients with rheumatoid arthritis. We detected a relation of this polymorphism to the levels of TNFα production by mononuclear cells of healthy donors. Changes in relative frequencies of the TNFα genotypes have been shown in rheumatoid arthritis. The -857С>T polymorphism of TNFα gene proved to be informative as a molecular marker reflecting efficiency of anti-TNFα therapy in rheumatoid arthritis.

Keywords