Patterned mechanical feedback establishes a global myosin gradient

Hannah J. Gustafson; Nikolas Claussen; Stefano De Renzis; Sebastian J. Streichan

doi:10.1038/s41467-022-34518-9

Nature Communications (Nov 2022)

Patterned mechanical feedback establishes a global myosin gradient

Hannah J. Gustafson,
Nikolas Claussen,
Stefano De Renzis,
Sebastian J. Streichan

Affiliations

Hannah J. Gustafson: Department of Physics, University of California Santa Barbara
Nikolas Claussen: Department of Physics, University of California Santa Barbara
Stefano De Renzis: EMBL Heidelberg
Sebastian J. Streichan: Department of Physics, University of California Santa Barbara

DOI: https://doi.org/10.1038/s41467-022-34518-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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How does DNA encode shape? Here, via in toto light sheet microscopy and optogenetic control of cellular forces, the authors show that spatially patterned mechanical feedback loops establish the cytoskeletal patterns driving axis elongation tissue flow in Drosophila.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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