THE DYNAMICS OF THE IMMUNE RESPONSEМ TO INFLUENZA IN CHILDREN TREATED WITH INTERFERON

Abstract

The paper presents clinical and laboratory study results of the immune response indicators dynamics in 199 children aged 1 year to 14 years with verified diagnosis of influenza depending on the type of immune response to the treatment with recombinant interferon alpha-2b (IFN) (Grippferon®, nasal drops). A total of 100 people received this medication, whereas 99 patients in the control group received pathogenetic therapy. The immune response type was determined on the basis of the polarisation coefficients (PC) suggested by the authors: PC1 = IL-4/IFN-γ and PC2 = IL-10/IFN-γ obtained by calculating the content ratio in the serum cytokines of IL-4 to IFN-γ and IL-10 to IFN-γ, responsible for the predominant type of immune response to antigen introduction. A good therapeutic efficacy of the intranasal medication of recombinant interferon alfa-2b was established for the treatment of influenza in children, given both the Th1and Th2-type immune response. This allows us to recommend this medication for use in children, regardless of the immune response type.

Keywords

• influenza
• children
• type of immune response
• interferon
• cytokines