Nature Communications (Oct 2022)
Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes
- Xiaoxiao Yuan,
- Ruirui Wang,
- Bing Han,
- ChengJun Sun,
- Ruimin Chen,
- Haiyan Wei,
- Linqi Chen,
- Hongwei Du,
- Guimei Li,
- Yu Yang,
- Xiaojuan Chen,
- Lanwei Cui,
- Zhenran Xu,
- Junfen Fu,
- Jin Wu,
- Wei Gu,
- Zhihong Chen,
- Xin Fang,
- Hongxiu Yang,
- Zhe Su,
- Jing Wu,
- Qiuyue Li,
- Miaoying Zhang,
- Yufeng Zhou,
- Lei Zhang,
- Guang Ji,
- Feihong Luo
Affiliations
- Xiaoxiao Yuan
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Ruirui Wang
- Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine
- Bing Han
- Institute of Pediatrics, Children’s Hospital of Fudan University
- ChengJun Sun
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Ruimin Chen
- Fuzhou Children’s Hospital of Fujian Medical University
- Haiyan Wei
- Department of Endocrinology and Inherited Metabolic, Children’s Hospital Affiliated to Zhengzhou University
- Linqi Chen
- Children’s Hospital of Soochow University
- Hongwei Du
- The First Hospital of Jilin University
- Guimei Li
- Department of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University
- Yu Yang
- The Affiliated Children’s Hospital of Nanchang University
- Xiaojuan Chen
- Department of Endocrinology, Genetics and Metabolism, The Children’s Hospital of Shanxi Province
- Lanwei Cui
- The First Affiliated Hospital of Harbin Medical University
- Zhenran Xu
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Junfen Fu
- Department of Endocrinology, Children’s Hospital, Zhejiang University School of Medicine
- Jin Wu
- Department of Pediatrics, West China Second University Hospital, Sichuan University
- Wei Gu
- Department of Endocrinology, Children’s Hospital of Nanjing Medical University
- Zhihong Chen
- Department of Neuroendocrinology Pediatrics, Affiliated Hospital of Qingdao University
- Xin Fang
- Fujian Medical University Union Hospital
- Hongxiu Yang
- Qingdao Women and Children’s Hospital
- Zhe Su
- Shenzhen Children’s Hospital
- Jing Wu
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Qiuyue Li
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Miaoying Zhang
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- Yufeng Zhou
- Institute of Pediatrics, Children’s Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University
- Lei Zhang
- Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine
- Guang Ji
- Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
- Feihong Luo
- Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University
- DOI
- https://doi.org/10.1038/s41467-022-33656-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.
