Anais Brasileiros de Dermatologia (Aug 2017)

Episodic angioedema associated with eosinophilia

  • Fang Liu,
  • Wenxing Hu,
  • Haibo Liu,
  • Min Zhang,
  • Hong Sang

DOI
https://doi.org/10.1590/abd1806-4841.20174351
Journal volume & issue
Vol. 92, no. 4
pp. 534 – 536

Abstract

Read online Read online

Abstract: We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.

Keywords