ANTIPHOSPHOLIPID ANTIBODIES, THEIR PATHOGENETIC AND DIAGNOSTIC ISSUES OBSTETRIC PRACTICE

Abstract

Not only thrombotic, but also “non-thrombotic” mechanisms of antiphospholipid antibodies are being actively studied in regard to their impact on the structure of reproductive losses and other complications of pregnancy. Non-thrombotic effects of APA include the damage of cells, the induction of apoptosis, the inhibition of proliferation, the suppression of human chorionic gonadotropin, the interference to the invasion of the trophoblast, and defectsof differentiation of the endometrium. Thrombotic effects are: widespread thrombosis, placental infarction, disruption of the annexin barrier, and anti-b2GPI and APC resistance.

Keywords

• antiphospholipid antibodies
• antiphospholipid syndrome
• complications of pregnancy
• catastrophis antiphospholipid syndrome