Neural Regeneration Research (Jan 2024)

The role of snapin in regulation of brain homeostasis

  • Jiawen Li,
  • Xinqi Huang,
  • Yumei An,
  • Xueshi Chen,
  • Yiyang Chen,
  • Mingyuan Xu,
  • Haiyan Shan,
  • Mingyang Zhang

DOI
https://doi.org/10.4103/1673-5374.389364
Journal volume & issue
Vol. 19, no. 8
pp. 1696 – 1701

Abstract

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Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

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