Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Minh-Thu Nguyen; Julia Uebele; Nimerta Kumari; Hiroshi Nakayama; Lena Peter; Olga Ticha; Anne-Kathrin Woischnig; Mathias Schmaler; Nina Khanna; Naoshi Dohmae; Bok Luel Lee; Isabelle Bekeredjian-Ding; Friedrich Götz

doi:10.1038/s41467-017-02234-4

Nature Communications (Dec 2017)

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Minh-Thu Nguyen,
Julia Uebele,
Nimerta Kumari,
Hiroshi Nakayama,
Lena Peter,
Olga Ticha,
Anne-Kathrin Woischnig,
Mathias Schmaler,
Nina Khanna,
Naoshi Dohmae,
Bok Luel Lee,
Isabelle Bekeredjian-Ding,
Friedrich Götz

Affiliations

Minh-Thu Nguyen: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
Julia Uebele: Paul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and Biomedicines
Nimerta Kumari: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
Hiroshi Nakayama: Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science
Lena Peter: Paul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and Biomedicines
Olga Ticha: Paul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and Biomedicines
Anne-Kathrin Woischnig: Laboratory of Infection Biology, Department of Biomedicine, University Hospital Basel
Mathias Schmaler: Laboratory of Infection Biology, Department of Biomedicine, University Hospital Basel
Nina Khanna: Laboratory of Infection Biology, Department of Biomedicine, University Hospital Basel
Naoshi Dohmae: Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science
Bok Luel Lee: National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University
Isabelle Bekeredjian-Ding: Paul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and Biomedicines
Friedrich Götz: Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen

DOI: https://doi.org/10.1038/s41467-017-02234-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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