Extramammary Paget’s Disease of the Vulva: Report of Two Cases
Christoforos S. Kosmidis,
Christina Sevva,
Panagiota Roulia,
Charilaos Koulouris,
Nikolaos Varsamis,
Georgios Koimtzis,
Vasiliki Theodorou,
Chrysi Maria Mystakidou,
Eleni Georgakoudi,
Georgios Anthimidis
Affiliations
Christoforos S. Kosmidis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Christina Sevva
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Panagiota Roulia
3rd Surgical Department, University General Hospital of Thessaloniki “AHEPA”, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece
Charilaos Koulouris
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Nikolaos Varsamis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Georgios Koimtzis
Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK
Vasiliki Theodorou
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Chrysi Maria Mystakidou
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Eleni Georgakoudi
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Georgios Anthimidis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool.
