Nature Communications (Jun 2022)
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder
- Elaine T. Lim,
- Yingleong Chan,
- Pepper Dawes,
- Xiaoge Guo,
- Serkan Erdin,
- Derek J. C. Tai,
- Songlei Liu,
- Julia M. Reichert,
- Mannix J. Burns,
- Ying Kai Chan,
- Jessica J. Chiang,
- Katharina Meyer,
- Xiaochang Zhang,
- Christopher A. Walsh,
- Bruce A. Yankner,
- Soumya Raychaudhuri,
- Joel N. Hirschhorn,
- James F. Gusella,
- Michael E. Talkowski,
- George M. Church
Affiliations
- Elaine T. Lim
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School
- Yingleong Chan
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School
- Pepper Dawes
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School
- Xiaoge Guo
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Serkan Erdin
- Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital
- Derek J. C. Tai
- Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital
- Songlei Liu
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Julia M. Reichert
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School
- Mannix J. Burns
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School
- Ying Kai Chan
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Jessica J. Chiang
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Katharina Meyer
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Xiaochang Zhang
- Department of Human Genetics, The University of Chicago
- Christopher A. Walsh
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Bruce A. Yankner
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Soumya Raychaudhuri
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Joel N. Hirschhorn
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- James F. Gusella
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Michael E. Talkowski
- Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital
- George M. Church
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-30968-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver genes.
