Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides

Rong-Hua Wang; Wei-Wei Xu; Hongli Wu; Yue Li; Jiang-Fei Li; Tao Zhang; Genping Huang; Mengchun Ye

doi:10.1038/s41467-022-35541-6

Nature Communications (Dec 2022)

Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides

Rong-Hua Wang,
Wei-Wei Xu,
Hongli Wu,
Yue Li,
Jiang-Fei Li,
Tao Zhang,
Genping Huang,
Mengchun Ye

Affiliations

Rong-Hua Wang: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Wei-Wei Xu: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Hongli Wu: Department of Chemistry, School of Science and Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University
Yue Li: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Jiang-Fei Li: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Tao Zhang: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Genping Huang: Department of Chemistry, School of Science and Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University
Mengchun Ye: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University

DOI: https://doi.org/10.1038/s41467-022-35541-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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