Атеросклероз (Dec 2015)
Lipid metabolism in women with coronary heart disease of different ages due to levels of sex hormones
Abstract
Objective: To analyze the basic components of the lipid profile of blood serum in patients with coronary artery disease based on the levels of follicle stimulating hormone (FSH), testosterone and age, to explore their association with anthropometric parameters and indices of insulin-glucose homeostasis. The study involved 285 women aged 35–65 years who have had myocardial infarction at least 30 days before the survey. The median age was 54.4 years (25 and 75 % percentile: 43.2 and 61.3 years). Patients were divided into age groups: 35–55 years and 56–65 years (first and second groups of age, respectively), as well as groups on levels of sex hormones FSH and ≥ <30 mIU / ml and ≥ testosterone and <3 nm / l. Using analysis of covariance it is determined that in women 35–55 years with coronary heart disease significant factor determining the back high density lipoprotein (HDL) cholesterol is FSH ≥30 mIU / ml (p = 0.001) for low density lipoprotein (LDL) cholesterol directly affects T ≥ 3 nmol / l (p = 0.002), and triglyceride (TG) levels is mediated by the direct influence of FSH ≥ 30 mIU / ml (p = 0.001). In the category of patients 56–65 years of multivariate analysis indicator back to determining the level of HDL cholesterol, the index was the HOMA-R (p = 0.015), TG directly dependent on blood glucose (p = 0.001), T ≥ 3 nmol / l (p = 0.007), the index of HOMA-R (p = 0.035) and FSH (p = 0.042). Thus, in women 35–55 years a fundamental factor in the development of hypertriglyceridemia and gipoalfaholesterinemia is a high level of follikulotropin; hyperandrogenism in this age group was accompanied by an increase LDL cholesterol. In patients 56–65 years raising of TG and lowering of HDL cholesterol is mediated primarily indices of insulin-glucose-axis, as well as smaller but independent influence of hyperandrogenism and FSH ≥ 30 mIU / ml.
