Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis

Abstract

Pneumococcal infection of the cerebrospinal fluid results in bacterial lysis, the release of toxic factors and induction of neuroinflammation. Here, the authors show that the virulence factor pneumolysin enhances the neuroinflammatory response to Streptococcus pneumoniae by the enhancement of endocytosis.