Nature Communications (Jun 2021)

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

  • Tamar Sofer,
  • Xiuwen Zheng,
  • Cecelia A. Laurie,
  • Stephanie M. Gogarten,
  • Jennifer A. Brody,
  • Matthew P. Conomos,
  • Joshua C. Bis,
  • Timothy A. Thornton,
  • Adam Szpiro,
  • Jeffrey R. O’Connell,
  • Ethan M. Lange,
  • Yan Gao,
  • L. Adrienne Cupples,
  • Bruce M. Psaty,
  • NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
  • Kenneth M. Rice

DOI
https://doi.org/10.1038/s41467-021-23655-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.