HISTOLOGICAL PICTURE OF THE PLACENTAE AND FEATURES OF CD34+ EXPRESSION IN THE CELLS OF ENDOTHELIUM OF CHORION VESSELS OF PREGNANTS WITH ANAEMIA

Abstract

Objective: To evaluate the histological features of the placentae and the degree of expression in the endothelial cells of the placental vessels of the endothelial marker CD34+ in women with anaemia and multiple births in the anamnesis. Methods: The subject of the study was placenta of 12 women with anemia and 6 healthy women. Evaluation of endothelial marker CD34+ expression was carried out qualitatively and quantitatively using the computer image analysis system «Morphology 5.0». Results: Patients with anaemia had expressed and moderately showed changes in the vascular bed of the chorion, regardless of the severity of the anaemia. With moderate anemia, there was chronic placental insufficiency (CPI) with a predominance of hypoplastic form. The revealed decrease in the expression of CD34+ in the placentae of women with anaemia confirms the disturbances in the functions of the vascular bed. Conclusion: Women with anaemia are disturbed by vascular adaptation during pregnancy, leading to CPI, the intensity of which increases as anaemia worsens.

Keywords

• anaemia
• placental insufficiency
• histological and immunohistological studies of the placenta
• endothelial marker cd34+..