npj Genomic Medicine (Apr 2017)
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
- Alexandre Reuben,
- Christine N. Spencer,
- Peter A. Prieto,
- Vancheswaran Gopalakrishnan,
- Sangeetha M. Reddy,
- John P. Miller,
- Xizeng Mao,
- Mariana Petaccia De Macedo,
- Jiong Chen,
- Xingzhi Song,
- Hong Jiang,
- Pei-Ling Chen,
- Hannah C. Beird,
- Haven R. Garber,
- Whijae Roh,
- Khalida Wani,
- Eveline Chen,
- Cara Haymaker,
- Marie-Andrée Forget,
- Latasha D. Little,
- Curtis Gumbs,
- Rebecca L. Thornton,
- Courtney W. Hudgens,
- Wei-Shen Chen,
- Jacob Austin-Breneman,
- Robert Szczepaniak Sloane,
- Luigi Nezi,
- Alexandria P. Cogdill,
- Chantale Bernatchez,
- Jason Roszik,
- Patrick Hwu,
- Scott E. Woodman,
- Lynda Chin,
- Hussein Tawbi,
- Michael A. Davies,
- Jeffrey E. Gershenwald,
- Rodabe N. Amaria,
- Isabella C. Glitza,
- Adi Diab,
- Sapna P. Patel,
- Jianhua Hu,
- Jeffrey E. Lee,
- Elizabeth A. Grimm,
- Michael T. Tetzlaff,
- Alexander J. Lazar,
- Ignacio I. Wistuba,
- Karen Clise-Dwyer,
- Brett W. Carter,
- Jianhua Zhang,
- P. Andrew Futreal,
- Padmanee Sharma,
- James P. Allison,
- Zachary A. Cooper,
- Jennifer A. Wargo
Affiliations
- Alexandre Reuben
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Christine N. Spencer
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Peter A. Prieto
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Vancheswaran Gopalakrishnan
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Sangeetha M. Reddy
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- John P. Miller
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Xizeng Mao
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Mariana Petaccia De Macedo
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Jiong Chen
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Xingzhi Song
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hong Jiang
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Pei-Ling Chen
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hannah C. Beird
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Haven R. Garber
- Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center
- Whijae Roh
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Khalida Wani
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Eveline Chen
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Cara Haymaker
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Marie-Andrée Forget
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Latasha D. Little
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Rebecca L. Thornton
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Courtney W. Hudgens
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Wei-Shen Chen
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jacob Austin-Breneman
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Robert Szczepaniak Sloane
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Luigi Nezi
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Alexandria P. Cogdill
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Chantale Bernatchez
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jason Roszik
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Scott E. Woodman
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Lynda Chin
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hussein Tawbi
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Michael A. Davies
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jeffrey E. Gershenwald
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Rodabe N. Amaria
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Isabella C. Glitza
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Adi Diab
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Sapna P. Patel
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jianhua Hu
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Jeffrey E. Lee
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Elizabeth A. Grimm
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Michael T. Tetzlaff
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Alexander J. Lazar
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Karen Clise-Dwyer
- Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center
- Brett W. Carter
- Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Padmanee Sharma
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- James P. Allison
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Zachary A. Cooper
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41525-017-0013-8
- Journal volume & issue
-
Vol. 2,
no. 1
pp. 1 – 11
Abstract
Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo from the University of Texas MD Anderson Cancer Center, Houston, USA, studied the radiological responses of 60 patients with metastatic melanoma, half of whom received targeted drug therapy and half of whom received an immune checkpoint inhibitor. The majority (83%) showed differences in responses across metastases. The group then profiled tumors in a subset, and found molecular and immune heterogeneity in different tumors within the same patient. Heterogeneity in mutational and immune profiles within tumors from individual patients could explain differences in treatment response. Knowing this, the authors emphasize the importance of acquiring biopsies from more than one tumor site in order to best tailor therapies to the features of metastatic cancer.
