Nature Communications (Sep 2018)

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

  • Yi-Ru Pan,
  • Chih-Cheng Chen,
  • Yu-Tien Chan,
  • Hsiao-Jung Wang,
  • Fan-Tso Chien,
  • Yeng-Long Chen,
  • Jing-Lan Liu,
  • Muh-Hwa Yang

DOI
https://doi.org/10.1038/s41467-018-06134-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.