Molecular screening of lfs and pssm-i diseases in arabian horse population in turkey

Abstract

Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MYO5A) leads frame shift mutation and premature termination of the protein. In the study, a total of 239 blood samples, taken from Anadolu (n=70), Karacabey (n=70) and Sultansuyu (n=99) stud farms were screened. Diseases related mutations were not detected in the sampled Arabian horse population.

Keywords

• arabian horses
• lfs
• pcr-rflp
• pssm-i