Nutrients (Jan 2022)

Dehydration Status Aggravates Early Renal Impairment in Children: A Longitudinal Study

  • Nubiya Amaerjiang,
  • Menglong Li,
  • Huidi Xiao,
  • Jiawulan Zunong,
  • Ziang Li,
  • Dayong Huang,
  • Sten H. Vermund,
  • Rafael Pérez-Escamilla,
  • Xiaofeng Jiang,
  • Yifei Hu

DOI
https://doi.org/10.3390/nu14020335
Journal volume & issue
Vol. 14, no. 2
p. 335

Abstract

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Dehydration is common in children for physiological and behavioral reasons. The objective of this study was to assess changes in hydration status and renal impairment across school weekdays. We conducted a longitudinal study of three repeated measures of urinalysis within one week in November 2019 in a child cohort in Beijing, China. We measured urine specific gravity (USG) to determine the dehydration status, and the concentration of β2-microglobulin (β2-MG) and microalbumin (MA) to assess renal function impairment among 1885 children with a mean age of 7.7 years old. The prevalence of dehydration was 61.9%, which was significantly higher in boys (64.3%). Using chi-square tests and linear mixed-effects regression models, we documented the trends of the renal indicators’ change over time among different hydration statuses. Compared to Mondays, there were apparent increases of β2-MG concentrations on Wednesdays (β = 0.029, p p p = 0.01) was significant in the euhydrated group. An increased trend of elevated β2-MG concentration was shown in both the euhydrated group (Z = −3.33, p p p 2-MG/MA, validated the consistent trends of renal function impairment in children with dehydration. Renal impairment trends worsened as a function of school days during the week and the dehydration status aggravated renal impairment during childhood across school weekdays, especially tubular abnormalities in children.

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