Biologic Therapies across Nasal Polyp Subtypes

Abstract

Chronic rhinosinusitis with nasal polyposis is a common inflammatory condition, with subtypes like aspirin-exacerbated respiratory disease, allergic fungal rhinosinusitis, and central compartment atopic disease sharing a common type 2 inflammatory pathway. Respiratory biologic therapies have been developed that target type 2 inflammation. In this article, we discuss the use of respiratory biologic therapies for nasal polyposis in general, as well as within the various subtypes of nasal polyps. Further, we discuss future roles of novel biologic therapies targeting type 2 inflammation in nasal polyposis.

Keywords

• nasal polyps
• chronic sinusitis
• biologic
• allergic fungal rhinosinusitis
• central compartment atopic disease
• aspirin-exacerbated respiratory disease