Mediterranean Journal of Hematology and Infectious Diseases (Feb 2015)

ClinicaI Reversible Myelopathy in T-Cell Lymphoblastic Lymphoma Treated with Nelarabine and Radiotherapy: Report of a Case and Review of Literature of an Increasing Complication

  • Maria Chiara Tisi,
  • Giuseppe Ausoni,
  • Maria Gabriella Vita,
  • Tommaso Tartaglione,
  • Mario Balducci,
  • Luca Laurenti,
  • Patrizia Chiusolo,
  • Stefan Hohaus,
  • Simona Sica

DOI
https://doi.org/10.4084/mjhid.2015.025
Journal volume & issue
Vol. 7, no. 1
pp. e2015025 – e2015025

Abstract

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To date, eleven cases of irreversible neurological defects in T- ALL patients treated with nelarabine have been described in the last 4 years, seven of these after stem cell transplantation (SCT) for T Lymphoblastic Lymphoma (T-LBL). Most of patients had an unfavorable outcome or irreversible damage. We report the case of a 41-year-old woman suffering from T-LBL who presented severe but reversible myelopathy after nelarabine based treatment and mediastinum radiotherapy, and we perform a review of literature.

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