PLoS ONE (May 2011)

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

  • Anthony T S Lo,
  • Noeris K Salam,
  • David E Hibbs,
  • Peter J Rutledge,
  • Matthew H Todd

DOI
https://doi.org/10.1371/journal.pone.0017446
Journal volume & issue
Vol. 6, no. 5
p. e17446

Abstract

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Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.