High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody–Drug Conjugate Aggregation and Drug Release

• Kenneth R. Durbin,
• M. Shannon Nottoli,
• Nathaniel D. Catron,
• Nicole Richwine,
• Gary J. Jenkins

Affiliations

Kenneth R. Durbin

†Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois, United States

M. Shannon Nottoli

†Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois, United States

Nathaniel D. Catron

‡Drug Product Development, AbbVie, Inc., North Chicago, Illinois, United States

Nicole Richwine

†Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois, United States

Gary J. Jenkins

†Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois, United States