S146: GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR (CBTKI) PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS: RESULTS FROM THE PHASE I/II BRUIN STUDY

• Jennifer R. Brown,
• Sai Prasad Desikan,
• Bastien Nguyen,
• Helen Won,
• Shady Tantawy,
• Samuel Clark Mcneely,
• Narasimha Marella,
• Kevin Ebata,
• Jennifer Woyach,
• Krish Patel,
• Constantine Tam,
• Toby Eyre,
• Chan Cheah,
• Nirav N Shah,
• Paolo Ghia,
• Wojciech Jurczak,
• Minna Balbas,
• Binoj Nair,
• Paolo Abada,
• Chunxiao Wang,
• Denise Wang,
• Anthony R. Mato,
• Varsha Gandhi,
• William G. Wierda

Affiliations

Jennifer R. Brown

1 Dana-Farber Cancer Institute and Harvard Medical School, Boston, United States

Sai Prasad Desikan

2 University of Texas MD Anderson Cancer Center, Houston, United States

Bastien Nguyen

3 Loxo@Lilly, Indianapolis, United States

Helen Won

3 Loxo@Lilly, Indianapolis, United States

Shady Tantawy

2 University of Texas MD Anderson Cancer Center, Houston, United States

Samuel Clark Mcneely

4 Eli Lilly and Company, Indianapolis, United States

Narasimha Marella

3 Loxo@Lilly, Indianapolis, United States

Kevin Ebata

3 Loxo@Lilly, Indianapolis, United States

Jennifer Woyach

5 The Ohio State University Comprehensive Cancer Center, Columbus, United States

Krish Patel

6 Swedish Cancer Institute, Seattle, United States, Center for Blood Disorders and Cellular Therapy, Seattle, United States

Constantine Tam

7 Alfred Health and Monash University, Melbourne, Australia

Toby Eyre

8 Churchill Cancer Center, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Chan Cheah

9 Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia

Nirav N Shah

10 Medical College of Wisconsin, Milwaukee, United States

Paolo Ghia

11 Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, United States

Wojciech Jurczak

12 Maria Sklodowska-Curie National Institute of Oncology, Krakow, Poland

Minna Balbas

3 Loxo@Lilly, Indianapolis, United States

Binoj Nair

3 Loxo@Lilly, Indianapolis, United States

Paolo Abada

3 Loxo@Lilly, Indianapolis, United States

Chunxiao Wang

4 Eli Lilly and Company, Indianapolis, United States

Denise Wang

3 Loxo@Lilly, Indianapolis, United States

Anthony R. Mato

13 Memorial Sloan Kettering Cancer Center, New York, United States

Varsha Gandhi

2 University of Texas MD Anderson Cancer Center, Houston, United States

William G. Wierda

2 University of Texas MD Anderson Cancer Center, Houston, United States