Angiomatoid Fibrous Histiocytoma (AFH) of the Right Arm: An Exceptional Case with Pulmonary Metastasis and Confirmatory EWSR1::CREB1 Translocation

Gerardo Cazzato; Carmelo Lupo; Nadia Casatta; Flavia Riefoli; Andrea Marzullo; Anna Colagrande; Eliano Cascardi; Senia Maria Rosaria Trabucco; Giuseppe Ingravallo; Biagio Moretti; Eugenio Maiorano; Vito Pesce; Leonardo Resta

doi:10.3390/diagnostics12112616

Diagnostics (Oct 2022)

Angiomatoid Fibrous Histiocytoma (AFH) of the Right Arm: An Exceptional Case with Pulmonary Metastasis and Confirmatory EWSR1::CREB1 Translocation

Gerardo Cazzato,
Carmelo Lupo,
Nadia Casatta,
Flavia Riefoli,
Andrea Marzullo,
Anna Colagrande,
Eliano Cascardi,
Senia Maria Rosaria Trabucco,
Giuseppe Ingravallo,
Biagio Moretti,
Eugenio Maiorano,
Vito Pesce,
Leonardo Resta

Affiliations

Gerardo Cazzato: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Carmelo Lupo: Innovation Department, Diapath S.P.A., Via Savoldini n.71, 24057 Martinengo, Italy
Nadia Casatta: Innovation Department, Diapath S.P.A., Via Savoldini n.71, 24057 Martinengo, Italy
Flavia Riefoli: Section of Orthopedics and Traumatology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy
Andrea Marzullo: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Anna Colagrande: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Eliano Cascardi: Department of Medical Sciences, University of Turin, 10124 Turin, Italy
Senia Maria Rosaria Trabucco: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Giuseppe Ingravallo: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Biagio Moretti: Section of Orthopedics and Traumatology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy
Eugenio Maiorano: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Vito Pesce: Section of Orthopedics and Traumatology, Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy
Leonardo Resta: Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy

DOI: https://doi.org/10.3390/diagnostics12112616
Journal volume & issue: Vol. 12, no. 11
p. 2616

Abstract

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Angiomatoid fibrous histiocytoma (AFH) is a rare neoplasm described for the first time by Enzinger in 1979, and classified by World Health Organization 2020 as intermediate malignant potential neoplasm. It mostly occurs in the subcutis and is characterized by varying proportions of epithelioid, ovoid and spindle cells in a nodular and syncytial growth pattern, with some hemorrhagic pseudovascular spaces. In this paper, we report the clinical case of a 62-year-old man who presented with AFH on the right arm, and relapsed three years after first surgical excision. After a further three years, the patient presented with an intramuscular localization of AFH, and 12 months after this, a pulmonary metastasis of AFH was diagnosed. Given the rarity of the spreading of AFH, we performed Fluorescence In Situ Hybridization (FISH) and we detected EWSR1::CREB1 gene fusion.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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