Iodine-Mediated Facile One-Pot Access to N-Aryl-2-benzoxazolamines

Abstract

Facile, iodine-mediated access to N-aryl-2-benzoxazolamines has been achieved in a one-pot manner under mild reaction conditions. Reaction of 2-aminophenols and aryl isothiocyanates afforded N-aryl-2-benzoxazolamines in the presence of molecular iodine and pyridine in tetrahydrofuran at room temperature in moderate to excellent yields.

Keywords

• iodine
• benzoxazolamine
• one-pot synthesis
• cyclode­sulfurization
• transition-metal-free