Optimization of the therapy for infection caused by Hеrpes virus 6 in newborns

Abstract

The purpose of the article is to optimize therapy in newborn children with infection caused by herpes virus type 6.Materials and methods. The first subgroup (I A) was made up of children who, along with symptom therapy and antiviral therapy with the drug acyclovir (n = 22).The second subgroup (I B) was made up of children who received antiviral therapy (acyclovir) and immunosetopical therapy (human immunoglobulin normal) (n = 21) in addition to the sympathic treatment. Expression of membrane markers of immunocompetent cells of periferic blood was determined on a flow laser cytofluorimeter «Beckman COULTER» Epics XL II. lymphocyte typing was carried out with monoclonal antibodies to СД3 differentiation clusters, СД4, СД8, CD16 СД19 by IMMUNOTECH (France).Results. At the patients who received a course of etiotropny and immunoreplacement therapy (IB subgroup) against the background of standard, registered authentically higher content of relative quantity of T-lymphocytes of CD3, at the expense of subpopulation T-helper of CD4 and also increase in CD16 and statistically significant decrease cytotoxic T-lymphocytes, CD8.Conclusions. In children of early age with infection caused by herpes virus type 6, administration of a complex therapy including acyclovir preparations, human immunoglobulin normal, is most effective.

Keywords

• newborns
• herpesvirus infection
• t-lymphocytes