Novel Natural and Synthetic Anticandidal Therapeutic Peptides to Combat Drug-Resistant Infections

Abstract

Candida species are considered as common flora of the healthy human mycobiome and occur on skin, mucosal surfaces of gastrointestinal and genitourinary tracks. Pathogenic Candida spp., reported to cause skin, vaginal and oral infections. Extensive use of antifungal agents has increased the drug resistance among pathogenic strains of Candida. To this effect, recently naturally occurring AMPs and synthetically modified peptides, are effectively being used as promising antifungal agents. Short peptides display better permeability to cross the yeast membrane, thus short antifungal peptide were designed using sequences from APD database. Natural peptides are potential source of antifungal agents. Considering above facts, we studied anticandidal potential of synthetic and natural peptides.

Keywords

• synthetic
• anticandidal
• therapeutic peptides