Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons

Franz Weber; Johnny Phong Hoang Do; Shinjae Chung; Kevin T. Beier; Mike Bikov; Mohammad Saffari Doost; Yang Dan

doi:10.1038/s41467-017-02765-w

Nature Communications (Jan 2018)

Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons

Franz Weber,
Johnny Phong Hoang Do,
Shinjae Chung,
Kevin T. Beier,
Mike Bikov,
Mohammad Saffari Doost,
Yang Dan

Affiliations

Franz Weber: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California
Johnny Phong Hoang Do: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California
Shinjae Chung: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California
Kevin T. Beier: Department of Biology, Howard Hughes Medical Institute, Stanford University
Mike Bikov: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California
Mohammad Saffari Doost: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California
Yang Dan: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California

DOI: https://doi.org/10.1038/s41467-017-02765-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

The vlPAG in the midbrain is known to suppress REM sleep, but the precise neural correlates are not known. Here, the authors record the activity of vlPAG GABAergic neurons during the sleep–wake cycle and report fast changes at REM sleep transitions and slower changes that correlate with REM sleep pressure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal