Nature Communications (Feb 2020)
Immuno-genomic landscape of osteosarcoma
- Chia-Chin Wu,
- Hannah C. Beird,
- J. Andrew Livingston,
- Shailesh Advani,
- Akash Mitra,
- Shaolong Cao,
- Alexandre Reuben,
- Davis Ingram,
- Wei-Lien Wang,
- Zhenlin Ju,
- Cheuk Hong Leung,
- Heather Lin,
- Youyun Zheng,
- Jason Roszik,
- Wenyi Wang,
- Shreyaskumar Patel,
- Robert S. Benjamin,
- Neeta Somaiah,
- Anthony P. Conley,
- Gordon B. Mills,
- Patrick Hwu,
- Richard Gorlick,
- Alexander Lazar,
- Najat C. Daw,
- Valerae Lewis,
- P. Andrew Futreal
Affiliations
- Chia-Chin Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hannah C. Beird
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- J. Andrew Livingston
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Shailesh Advani
- Department of Pediatrics, The University of Texas MD Anderson Cancer Center
- Akash Mitra
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Shaolong Cao
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Alexandre Reuben
- Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Davis Ingram
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Wei-Lien Wang
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Zhenlin Ju
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Cheuk Hong Leung
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Heather Lin
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Youyun Zheng
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jason Roszik
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Wenyi Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Shreyaskumar Patel
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Robert S. Benjamin
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Neeta Somaiah
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Anthony P. Conley
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Gordon B. Mills
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Richard Gorlick
- Department of Pediatrics, The University of Texas MD Anderson Cancer Center
- Alexander Lazar
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Najat C. Daw
- Department of Pediatrics, The University of Texas MD Anderson Cancer Center
- Valerae Lewis
- Department of Orthopedic Oncology, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-14646-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment.
