1,3-Indanedione: An versatile building block

Abstract

Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl compound with three contiguous reactive electrophilic and nucleophilic sites. The easily prepared 2-arylidene-1,3-indanediones are active α,β-unsaturated carbonyl compounds and could act as 1,3-dipolarophile, 1,4-dienophile and 1-oxa-1,3-diene, etc. On the other hand, the homodimer (bindone) and cyclotrimer (truxenone) derived from base-catalyzed self-condensation of 1,3-indanedione are also reactive carbonyl compounds. Therefore, 1,3-indanedione and its derivatives can be employed as key substrates in various domino and multicomponent reactions. In this review, we summarized the recent progress on the domino and multicomponent reactions of 1,3-indanedione, especially on our achievements on the synthetic applications for the complex indanone-containing carbocyclic and heterocyclic compounds.

Keywords

• 1,3-Indanedione
• Bindone
• Indeno[1,2-a]fluorine
• Domino reaction
• Multicomponent reaction