Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages

Joyce J. Thompson; Daniel J. Lee; Apratim Mitra; Sarah Frail; Ryan K. Dale; Pedro P. Rocha

doi:10.1038/s41467-022-31938-5

Nature Communications (Jul 2022)

Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages

Joyce J. Thompson,
Daniel J. Lee,
Apratim Mitra,
Sarah Frail,
Ryan K. Dale,
Pedro P. Rocha

Affiliations

Joyce J. Thompson: Unit on Genome Structure and Regulation, National Institute of Child Health and Human Development, National Institutes of Health
Daniel J. Lee: Unit on Genome Structure and Regulation, National Institute of Child Health and Human Development, National Institutes of Health
Apratim Mitra: Bioinformatics and Scientific Programming Core, National Institute of Child Health and Human Development, National Institutes of Health
Sarah Frail: Unit on Genome Structure and Regulation, National Institute of Child Health and Human Development, National Institutes of Health
Ryan K. Dale: Bioinformatics and Scientific Programming Core, National Institute of Child Health and Human Development, National Institutes of Health
Pedro P. Rocha: Unit on Genome Structure and Regulation, National Institute of Child Health and Human Development, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-022-31938-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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The authors show that the transcription factors NANOG and GATA6 co-bind the same enhancers in common progenitors before divergent epiblast and primitive endoderm lineages emerge. This may help maintain plasticity at early stages and facilitate bifurcation into distinct lineages

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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