Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol

• ,
• Neil Marlow,
• Spyros Bakalis,
• Luigi Raio,
• Roland Devlieger,
• Aris Papageorghiou,
• Rebecca Cannings-John,
• Christoph C Lees,
• Kate Walker,
• Andrew Breeze,
• Jørgen Linde,
• Andrew Sharp,
• Wessel Ganzevoort,
• Jim G Thornton,
• Julia Townson,
• Tanja Groten,
• Irene Cetin,
• Peter Lindgren,
• Kinga Chalubinski,
• Federico Prefumo,
• Edward Mullins,
• Astrid Berger,
• Sofia Amylidi-Mohr,
• Cathrine Ebbing,
• Sergio Ferrazzani,
• Ladislav Krofta,
• Bianca Masturzo,
• Amarnath Bhide,
• Ilenia Mappa,
• Hans Wolf,
• Tiziana Frusca,
• Kurt Hecher,
• Tullio Ghi,
• Andrea Smith,
• Silvia Salvi,
• Wilfried Gyselaers,
• Raffaele Napolitano,
• MARK KILBY,
• Erich Cosmi,
• Claire Potter,
• Enrico Ferrazzi,
• Baskaran Thilaganathan,
• Basky Thilaganathan,
• Sven Kehl,
• Dietmar Schlembach,
• Christine Morfeld,
• Bronacha Mylrea-Foley,
• Christina Ammari,
• Birgit Arabin,
• Eva Bergman,
• Caterina Bilardo,
• Julia Binder,
• Jana Brodszki,
• Pavel Calda,
• Andrej Černý,
• Elena Cesari,
• Andrea Dall'Asta,
• Anke Diemert,
• Torbjørn Eggebø,
• Ilaria Fantasia,
• Jenny Goodier,
• Patrick Greimel,
• Wassim Hassan,
• Constantin Von Kaisenberg,
• Alexey Kholin,
• Philipp Klaritsch,
• Silvia Lobmaier,
• Karel Marsal,
• Giuseppe M Maruotti,
• Federico Mecacci,
• Kirsti Myklestad,
• Eva Ostermayer,
• Jute Richter,
• Ragnar Kvie Sande,
• Ekkehard Schleußner,
• Tamara Stampalija,
• Herbert Valensise,
• Gerard HA Visser,
• Ling Wee,
• Andy Simm,
• Angela Ramoni,
• Barry Lloyd,
• Christopher Lloyd,
• Claudia Seidig,
• Danielle Thornton,
• Elena Mantovani,
• Emanuela Taricco,
• Emma Bertucci,
• Ferenc Macsali,
• Francesca Ferrari,
• Francesco D'Antonio,
• Francesco Picciotto,
• Gareth Waring,
• Georgios Rembouskos,
• Giuseppe Cali,
• Giuseppe Rizzo,
• Grazia Maria Tiralongo,
• Ilaria Giuditta Ramezzana,
• Ioannis Kyvernitakis,
• Iris Derwig,
• Iris Dressler-Steinbach,
• Jiří Vojěch,
• Karen Melchiorre,
• Kristiina Rull,
• Kristina Kernell,
• Lars Brodowski,
• Laura Sarno,
• Ligita Jokibkiene,
• Liina Rajasalu,
• Lina-Ana Fryszer,
• Louisa Jones,
• Magdalena Bednarek-Jędrzejek,
• Makrina Savvidou,
• Maria Stefopoulou,
• Marianna Rambaldi,
• Nia Jones,
• Nicola Fratelli,
• Nishigandh Deole,
• Petra Pateisky,
• Pilar Palmrich,
• Ralf Schild,
• Sabina Ondrová,
• Sarah Gumpert,
• Sasha Taylor,
• Saskia Schmidt,
• Sebastian Kwiatkowski,
• Serena Caterina,
• Serena Ottanelli,
• Serena Simeone,
• Silvia Visentin,
• Stefan Verlohren,
• Susanne Dargel,
• Tatjana Radaelli,
• Tinne Mesens,
• Tiziana Fanelli,
• Tuuli Haabpiht,
• Yvonne Heiman,
• Zulfiya Khodzhaeva,
• Christoph Brezinka,
• Sanne Gordijn,
• Abin Thomas

Affiliations

USAID, Washington, District of Columbia, USA

Neil Marlow

1 Institute for Women`s Health, University College London, London, UK

Spyros Bakalis

1 Department of Obstetrics, Maternal and Fetal Medicine, Guy’s and Saint Thomas’ NHS Foundation Trust, London, UK

Luigi Raio

17 Department of Obstetrics and Gynaecology, University Hospital of Bern, Inselspital, Bern, Switzerland

Roland Devlieger

2 Research Unit Organ Systems, Department of Development and Regeneration, Katholieke Universiteit Leuven Groep Biomedische Wetenschappen, Leuven, Belgium

Aris Papageorghiou

7 Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United Kingdom

Rebecca Cannings-John

Centre for Trials Research, Cardiff University, Cardiff, UK

Christoph C Lees

1 Department of Surgery and Cancer, Imperial College London, London, UK

Kate Walker

Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

Andrew Breeze

2 Fetal Medicine Unit, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK

Jørgen Linde

2 Faculty of Health Sciences, University of Stavanger, Stavanger, Norway

Andrew Sharp

4 Department of Cardiology, Royal Devon and Exeter Hospital, Exeter, UK

Wessel Ganzevoort

Obstetrics and Gynaecology, Amsterdam Universitair Medische Centra, Amsterdam, The Netherlands

Jim G Thornton

professor of obstetrics and gynaecology

Julia Townson

Centre for Trials Research, Cardiff University, Cardiff, UK

Tanja Groten

1 Department of Obstetrics, Universitätsklinikum Jena (University Hospital Jena), Jena, Germany

Irene Cetin

15 Department of Obstetrics & Gynaecology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic

Peter Lindgren

7 Medical Management Center, Department of Learning, Information, Management and Ethics, Karolinska Institutet, Stockholm, Sweden

Kinga Chalubinski

Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Vienna, Austria

Federico Prefumo

7 Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

Edward Mullins

Department of Metabolism, Surgery and Cancer, Imperial College London Faculty of Medicine, London, UK

Astrid Berger

Tumorbank Ovarian Cancer Network, Berlin, Germany

Sofia Amylidi-Mohr

Department for Obstetrics and Gynecology, Inselspital Bern Universitätsklinik für Frauenheilkunde, Bern, BE, Switzerland

Cathrine Ebbing

5 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway

Sergio Ferrazzani

Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario ‘A. Gemelli’, Catholic University of Sacred Heart, Rome, Italy

Ladislav Krofta

4 Institute for the care of mother and child, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Bianca Masturzo

Amarnath Bhide

Obstetrics and Gynaecology, St George’s University Hospitals Trust, London, UK

Ilenia Mappa

2 Department of Obstetrics and Gynecology, Fondazione Policlinico Universitario A. Gemelli—Università Cattolica del Sacro Cuore, Rome, Italy

Hans Wolf

Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands

Tiziana Frusca

Department of Gynecology and Obstetrics, University of Parma, Parma;

Kurt Hecher

3Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Tullio Ghi

Departments of Obstetrics and Gynecology, and

Andrea Smith

2 Wolverhampton CCG, Wolverhampton Clinical Commissioning Group, Wolverhampton, UK

Silvia Salvi

1 Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy

Wilfried Gyselaers

Department of Obstetrics and Gynaecology, Hospital Oost-Limburg, Genk, Belgium

Raffaele Napolitano

2Cheltenham General Hospital, UK

MARK KILBY

Clinical senior lecturer

Erich Cosmi

Obstetrics and Gynecology Clinic, Padua University Hospital, Padova, Italy

Claire Potter

NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, UK

Enrico Ferrazzi

2Istituto Ortopedico Gaetano Pini, University of Milan, Milan

Baskaran Thilaganathan

director

Basky Thilaganathan

Obstetrics and Gynecology, University of London Saint George`s, London, UK

Sven Kehl

Dietmar Schlembach

41 Vivantes Network for Health, Clinicum Neukoelln, Clinic for Obstetric Medicine, Berlin, Germany

Christine Morfeld

Bronacha Mylrea-Foley

1 Imperial College London, Obstetrics and Gynaecology, Queen Charlotte`s & Chelsea Hospital London, London, UK

Christina Ammari

5 University College London Hospitals NHS Foundation Trust, London, UK

Birgit Arabin

6 Department of Obstetrics Charite, Humboldt University of Berlin, Berlin, Germany

Eva Bergman

8 Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

Caterina Bilardo

10 Department of Obstetrics Amsterdam, Vrije Universiteit Amsterdam, Noord-Holland, Netherlands

Julia Binder

11 Department of Obstetrics and Fetomaternal Medicine, Medical University of Vienna, Vienna, Austria

Jana Brodszki

13 Department of Obstetrics and Gynecology, Lund Skanes universitetssjukhus Lund, Skåne, Sweden

Pavel Calda

14 Department of Obstetrics and Gynaecology, Charles University, Praha, Czech Republic

Andrej Černý

15 Department of Obstetrics & Gynaecology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic

Elena Cesari

16 Centre for Trials Research, Cardiff University, Cardiff, UK

Andrea Dall'Asta

17 Department of Obstetrics and Gynecology, Vittore Buzzi Hospital, University of Milan, Milan, Italy

Anke Diemert

4 Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Torbjørn Eggebø

19 St Olav’s Hospital, Trondheim, Norway

Ilaria Fantasia

20 Unit of Fetal Medicine and Prenatal Diagnosis, RCCS materno infantile Burlo Garofolo Dipartimento di Pediatria, Trieste, Italy

Jenny Goodier

22 Department of Obstetrics & Gynecology, University of Parma, Parma, Italy

Patrick Greimel

23 Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria

Wassim Hassan

25 Obstetrics & Gynaecology, East Suffolk and North Essex NHS Foundation Trust, Colchester Hospital, Colchester, UK

Constantin Von Kaisenberg

26 Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany

Alexey Kholin

27 National Medical Research Center for Obstetrics, Gynecology & Perinatology, Moscow, Russia

Philipp Klaritsch

25 Obstetrics & Gynaecology, East Suffolk and North Essex NHS Foundation Trust, Colchester Hospital, Colchester, UK

Silvia Lobmaier

30 Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention & Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden

Karel Marsal

27 National Medical Research Center for Obstetrics, Gynecology & Perinatology, Moscow, Russia

Giuseppe M Maruotti

31 Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Federico Mecacci

32 Obstetrics and Gynaecology, Faculty of Medicine, Lunds Universitet, Lund, Sweden

Kirsti Myklestad

33 Department of Neurosciences, Reproductive and Dentistry Sciences, Federico II University Hospital, Napoli, Italy

Eva Ostermayer

31 Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Jute Richter

39 Department of Obstetrics and Gynaecology, Stavanger University Hospital, Stavanger, Norway

Ragnar Kvie Sande

40 Department of Gynecology and Obstetrics, Katholieke Universiteit Leuven, Leuven, Belgium

Ekkehard Schleußner

42 Klinik für Geburtsmedizin, Universitätsklinikum Jena, Jena, Germany

Tamara Stampalija

41 Vivantes Network for Health, Clinicum Neukoelln, Clinic for Obstetric Medicine, Berlin, Germany

Herbert Valensise

43 Division of Obstetrics and Gynaecology Policlinico Casilino, Roma, Italy

Gerard HA Visser

44 Department of Obstetrics, University Medical Center, Utrecht University, Utrecht, The Netherlands

Ling Wee

45 Obstetrics And Gynaecology, Princess Alexandra Hospital NHS Trust, Harlow, UK

Andy Simm

Angela Ramoni

Barry Lloyd

Christopher Lloyd

Claudia Seidig

Danielle Thornton

Elena Mantovani

Emanuela Taricco

Emma Bertucci

Ferenc Macsali

Francesca Ferrari

Francesco D'Antonio

Francesco Picciotto

Gareth Waring

Georgios Rembouskos

Giuseppe Cali

Giuseppe Rizzo

Grazia Maria Tiralongo

Ilaria Giuditta Ramezzana

Ioannis Kyvernitakis

Iris Derwig

Iris Dressler-Steinbach

Jiří Vojěch

Karen Melchiorre

Kristiina Rull

Kristina Kernell

Lars Brodowski

Laura Sarno

Ligita Jokibkiene

Liina Rajasalu

Lina-Ana Fryszer

Louisa Jones

Magdalena Bednarek-Jędrzejek

Makrina Savvidou

Maria Stefopoulou

Marianna Rambaldi

Nia Jones

Nicola Fratelli

Nishigandh Deole

Petra Pateisky

Pilar Palmrich

Ralf Schild

Sabina Ondrová

Sarah Gumpert

Sasha Taylor

Saskia Schmidt

Sebastian Kwiatkowski

Serena Caterina

Serena Ottanelli

Serena Simeone

Silvia Visentin

Stefan Verlohren

Susanne Dargel

Tatjana Radaelli

Tinne Mesens

Tiziana Fanelli

Tuuli Haabpiht

Yvonne Heiman

Zulfiya Khodzhaeva

Christoph Brezinka

1 Imperial College London, Obstetrics and Gynaecology, Queen Charlotte`s & Chelsea Hospital London, London, UK

Sanne Gordijn

2 Department of Obstetrics and Gynaecology, University of Nottingham, City hospital, Nottingham, UK

Abin Thomas